H673 Degenerative Myelopathy, DM - Page 2 of 2

Neuronal Ceroid Lipofuscinosis 12 (NCL 12) – Australian Cattle Dog

Neuronal Ceroid Lipofuscinosis (NCL) is the name referring to a wide array of degenerative neurological conditions which cause progressive nerve damage, resulting in a loss of mobility and vision, and ultimately death. This variant, occurring in the Australian Cattle Dog, is known as Neuronal Ceroid Lipofuscinosis 12 (NCL12), and is caused by a recessive mutation to the gene ATP13A2. A related variant also occurs in the Tibetan Terrier.

Neuronal Ceroid Lipofuscinosis 8 (NCL8) – Saluki

Neuronal Ceroid Lipofuscinosis (NCL) is the name referring to a wide array of degenerative neurological conditions which cause progressive nerve damage, resulting in a loss of mobility and vision, and ultimately death. This particular variant of the disorder, known as Neuronal Ceroid Lipofuscinosis 8 (NCL8), is caused by a recessive mutation to the gene CLN8. The specific mutation analysed in this test is found in the Saluki. Closely related variants also occur in the English Setter, Australian Shepherd, German Shorthaired Pointer and Alpenländische Dachsbracke.

Neuronal Ceroid Lipofuscinosis 1 (NCL1) – Cane Corso

Neuronal Ceroid Lipofuscinosis (NCL) is the name referring to a wide array of degenerative neurological conditions which cause progressive nerve damage, resulting in a loss of mobility and vision, and ultimately death. The variant of the disease analysed in this test, known as Neuronal Ceroid Lipofuscinosis 1 (NCL1), is caused by a recessive mutation to the gene PPT1, and is found in the Cane Corso. A closely related variant of NCL1 is found in the Dachshund.

Hereditary Ataxia – Australian Shepherd

Progressive Degenerative Myeloencephalopathy is a form of hereditary ataxia, a severe neural disorder that causes loss of coordination, muscle weakness and sensory problems. Occurring in the Australian Shepherd, the disorder is caused by a recessive mutation to the gene PNPLA8. The disease is progressive, and may require euthanasia due to increasingly poor quality of life.

Neuroaxonal Dystrophy (NAD) – Papillon

Neuroaxonal Dystrophy (NAD) is a severe, degenerative neurological disease that causes a loss of muscle coordination and damages the senses. The disorder occurs in the Papillon, and is caused by a recessive mutation to the gene PLA2G6.

Neuroaxonal Dystrophy (NAD) – Rottweiler

Canine neuroaxonal dystrophy (NAD) is a degenerative, recessive neurological disease of young adult Rottweiler dogs. The disease is characterised by targeting sensory axon terminals by axonal spheroids, whereby axonal swellings occur in the central or peripheral nervous system. The neurological disorder is caused by a missense mutation within the Vacuolar Protein Sorting 11 (VPS11).

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