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Canine degenerative myelopathy (DM) is an incurable progressive neurodegenerative disease of the spinal cord.
Specifications
| Breeds | American Water Spaniel, Borzoi, Canaan Dog, Northern Inuit Dog, Poodle (Miniature), Smooth Collie, Wire Fox Terrier, American Eskimo dog, Australian Shepherd, Bernese Mountain dog, Bloodhound, Border Collie, Boxer, Cardigan Welsh Corgi, Cavalier King Charles Spaniel, Chesapeake Bay Retriever, Collie, English Springer Spaniel, German Shepherd, Golden Retriever, Hovawart, Irish Soft-Coated Wheaten Terrier, Jack Russell Terrier, Kerry Blue Terrier, Kuvasz, Nova Scotia Duck Tolling Retriever, Pembroke Welsh Corgi, Pug, Rhodesian Ridgeback, Rough Collie, Shetland Sheepdog, Siberian Husky, Welsh Terrier |
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| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Canine degenerative myelopathy (DM) is an incurable progressive neurodegenerative disease of the spinal cord. Neurodegenerative diseases are characterised by progressive loss of neurons in the central nervous system (CNS) which leads to deficiencies in function. In the case of DM, the affected region is the spinal cord, which results in ataxia (a loss of coordination). DM is similar in many ways to Amyotrophic Lateral Sclerosis (ALS) in humans.
This variant of the disease, sometimes designated as SOD1B or as Degenerative Myelopathy Exon 2, occurs in many different breeds. It is caused by a recessive mutation to the gene SOD1.
Clinical features
Extra information
References
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